What are Semi Solids and Liquids in a pharmaceutical manufacturing context?
Semi Solids and Liquids Definition | There are a large range of semi-solid and liquid formulation techniques employed in pharmaceutical manufacturing. Self-emulsifying pharmaceutical formulations are used to improve the oral bioavailability of poorly soluble drugs, typically increasing Cmax and decreasing Tmax concentrations. These formulations consist of a surfactant, lipid and cosolvent in varying concentrations which form a microemulsion in the presence of water. They are typically presented in gelatin capsules. These formulations are commonly known as Self Emulsifying Drug Delivery Systems (SEDDS). Simple liquid formulations consist of a drug in solution presented in a capsule. The solvent is determined by the chemistry and required concentration of the drug. Precipitation of the drug can be triggered by the dilution of the capsule at specific pH ranges.